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Pharmacology: Pharmacodynamics: Mechanism of action: Hydralazine reduces peripheral resistance and blood pressure as a result of direct vasodilatory effect on vascular smooth muscle; the effect on arterioles is greater than on veins.
Pharmacokinetics: Absorption: Rapidly absorbed after oral administration.
Metabolism: Hepatically acetylate; extensive first-pass effect (oral).
Excretion: Urine (as metabolite).
Time to peak: 1-2 hours.
Half-life elimination: 3-7 hours.
Protein-binding: 87%.
Bioavailability: Increase with food.
